Let’s Talk Titers: Avoid Over-Vaccinating Your Cat


Guest post by W. Jean Dodds, DVM

Jeannie recently adopted a three-year-old cat from her local shelter. Determined to give her new friend a healthy life, she decided not to have him vaccinated every year. She’d heard that vaccine titers were a good alternative to annual boosters, so she found a veterinarian who offers this option and asked him for more information.

Compelling evidence implicates vaccines in triggering various immune-mediated and other chronic disorders (vaccinosis). In cats, for example, aggressive tumors called fibrosarcomas can occasionally arise at the site of vaccination. While some of these problems have been traced to contaminated or poorly attenuated batches of vaccine that revert to virulence, others apparently reflect a genetic predisposition in an animal to react adversely when given the single (monovalent) or multiple antigen “combo” (polyvalent) products routinely administered to animals. Certain susceptible breeds or families of animal appear to be at increased risk for severe and lingering adverse vaccine reactions.

What is titer testing?

Titer testing for a particular infectious agent measures the presence and level of antibodies in an animal’s blood. These antibodies reflect the combination of any natural exposure and vaccination, and were created when the animal’s immune system responded to the antigens introduced into his body.

The presence of a measurable serum antibody titer indicates the presence of “immune memory”, and signifies protection from disease. Titers do not distinguish between immunity generated by vaccination and/or by exposure to the disease, although the magnitude of immunity produced just by vaccination is usually lower. When an adequate immune memory has already been established, there is little reason to introduce unnecessary antigen, adjuvant and preservatives by administering booster vaccines. If titer levels are adequate, your cat has protection against future exposure to the infectious agent, and revaccination is not needed.

By measuring titers every three years, or more often if desired, you can determine whether your cat’s circulating immune response has fallen below levels of adequate “immune memory”. In that event, an appropriate vaccine booster can be administered.

A “motion picture that plays for years”

Some veterinarians have challenged the validity of using vaccine titer testing to assess whether individual animals are protected against common, clinically important infectious diseases. With all due respect, this represents a misunderstanding of what has been called the “fallacy of titer testing”, because research has shown that once an animal’s titer stabilizes, it is likely to remain constant for many years. It is often said that the antibody level detected by a titer test is “only a snapshot in time”. That’s simply not true — it is more like a “motion picture that plays for years”. A cat with an adequate antibody level doesn’t need to be revaccinated, especially when the vaccine could cause an adverse reaction (hypersensitivity disorder). You should avoid vaccinating cats that are already protected.

Positive versus negative results

A positive titer test result is fairly straightforward, but a negative titer test result is more difficult to interpret, because it’s is not the same thing as a zero titer and doesn’t necessarily mean the cat is unprotected. A negative result usually means the titer has failed to reach the threshold of providing protective immunity. For the clinically important panleukopenia in cats, a negative or zero antibody titer indicates the animal is likely to be unprotected against feline panleukopenia virus.

High efficacy

More than a decade of experience with vaccine titer testing demonstrates this procedure is effective. Published studies in refereed journals show that 90% to 98% of cats that have been properly vaccinated develop good measurable antibody titers to the infectious agent being measured. Using titer testing as a means to assess vaccine-induced protection means you can avoid giving your cat needless and unwise booster vaccinations. So next time you set up a veterinary appointment for your cat, do as Jeannie did and ask if they offer titer testing.

Jean Dodds, DVM is the founder of Hemopet, which encompasses the world’s first non-profit animal blood bank and Greyhound resuce/adoption program as well as Hemolife, a veterinary diagnostic labarotary using patented, environmentally friendly “green” methods, prompt turn around time and personal consultation.

Reprinted with permission of Animal Wellness Magazine ©2012 

Photo by Lindsey Turner, Flickr Creative Commons

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12 Comments on Let’s Talk Titers: Avoid Over-Vaccinating Your Cat

  1. Dog Walker
    July 23, 2013 at 3:58 am (8 years ago)

    I’d say this applies to dogs as well.

    The anti-body figures are quite reassuring too.

    Great article Ingrid, thanks!

    • Ingrid
      July 23, 2013 at 7:41 am (8 years ago)

      Yes, this does apply to dogs as well.

  2. Emma
    July 10, 2013 at 7:59 am (8 years ago)

    Wow this is certainly an eye-opening article and excellent cat advice. Is the same true for dogs I wonder? Do you think that vets are generally too keen to vaccinate?

    • Ingrid
      July 10, 2013 at 8:01 am (8 years ago)

      Emma, the same does apply to dogs.

  3. Michelle
    December 6, 2012 at 10:21 pm (9 years ago)

    Great information, I hope more people start doing this. And I agree with Gina this is great for dogs too.


  4. Gina
    May 1, 2012 at 9:47 am (9 years ago)

    When I lived in Los Angeles I worked for a Vet that ‘s been doing this for years on dogs. Not sure if he’s now doing cats. He also offers holistic treatment. If anyone’s looking in the Southern California area………….Dr. Richard Palmquist.

  5. Robin Olson
    April 23, 2012 at 4:19 pm (9 years ago)

    I’m a BIG fan of running titers instead of vaccinating if my cats already have the
    basics on board. I hope more people look into doing this. Great article!

    • Ingrid
      April 23, 2012 at 5:34 pm (9 years ago)

      I can’t take credit for the article, Robin, but I felt it was an important topic to share. Dr. Dodds covered in a way that makes a complex topic easy to understand.

  6. Jenny | Floppycats.com
    April 23, 2012 at 11:17 am (9 years ago)

    loved learning about this! thank you for sharing it. now i need to find a vet that does it!

    • Ingrid
      April 23, 2012 at 1:41 pm (9 years ago)

      Jenny, most vets will offer this service if you request it. The blood test is sent to the same major labs that handles other blood testing.


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