Conscious Cat

October 24, 2011 166 Comments

Chemotherapy for Cats

Posted by Ingrid

Feebee cat in blue chair

While cancer in cats is not as common as it in dogs, it is still one of the leading causes of death in older cats. According to the Animal Cancer Foundation, 6 million cats will be diagnosed with cancer in the United States along. And because cats are masters at masking illness, it is often harder to detect.

Cancer used to be a death sentence for cats, but recent advances in feline cancer research have made treatment possible in many cases. Just like with human cancers, early detection is key to successful treatment.

Treatment options for cats are almost as varied as treatment options for human cancers, and will depend on the type of cancer. Surgery is the most common treatment for any lumps or growths that need to be removed. In some cases, surgery can be curative. Other cancers may require chemotherapy or radiation.

How chemotherapy works

Chemotherapy uses drugs with the objective to kill cancer cells with the least possible amount of damage to normal, healthy cells. In human medicine, the goal of chemotherapy is to achieve a cure. In cats, chemotherapy is aimed at controlling the disease and achieving a period of remission for the cat. Chemotherapy is typically used for cancers that affect multiple sites. Lymphoma is the most common form of feline cancer that is treated with chemotherapy. The drugs used in veterinary chemotherapy are frequently the same drugs used in human medicine.

Most cats tolerate chemotherapy well

Most cats tolerate chemotherapy well. Some cats may experience side effects such as vomiting, diarrhea or poor appetite, but these side effects are usually mild and can be managed with supportive care. Only a very small number of cats on chemotherapy will require hospitalization due to the side effects of chemotherapy. Unlike humans, cats will not lose all their hair. Most cats will lose their whiskers, and shaved hair will be slow to grow back, but substantial hair loss is uncommon.

Support your cat’s immune system

It is important to support your cat’s immune system while she is undergoing chemotherapy. One of the foundations of a healthy immune system is diet. Typically, veterinarians recommend a high protein, low carb, moderate fat diet for pets with cancer. A high quality grain-free canned diet will probably be your best choice for your feline cancer patient.

Even though I’m a proponent of raw feeding, I’m on the fence as to whether raw diets are appropriate for cats with cancer. On the one hand, there are numerous anecdotal reports of miracle cures when pets with cancer were fed a raw diet, on the other hand, I don’t know whether feeding a raw diet to an immunocompromised pet is necessarily a good idea. Check with a veterinarian who is familiar with raw feeding whether a raw diet is appropriate for your cat while she is undergoing chemotherapy.

Supplements and herbs

Supplements and herbs can provide immune system support during treatment. Probiotics not only help maintain a healthy gut flora, but also boost the immune system. Anti-oxidants and increased amounts of omega-3-fatty acids may also be indicated. Check with your veterinarian to determine which supplements are indicated for your cat.

Supportive therapies such as acupuncture, Reiki or other forms of energy healing can support your cat through her treatment. These therapies will not interfere with conventional medical treatment.

How will you know whether chemotherapy was successful?

A cat in remission doesn’t look any different from a cancer-free cat. Typically, a successful remission means that lymphnodes will go down to normal size, and if there were any signs of illness that were related to the cancer, they will disappear. Remission can last anywhere from weeks to months, and for some lucky cats, even several years.

My personal experience with feline cancer

My first cat, Feebee, was diagnosed with intestinal lymphoma when he was 15 years old. He tolerated his chemotherapy protocol of a combination of Vincristine injections and oral Cytoxan and prednisone well. He would be a little subdued for about 24 hours following treatment. His appetite wasn’t that great during that period, and he slept a lot more than usual, but the rest of the time, his quality of life was good.

After seven months, he stopped responding to the chemotherapy. My vet gave me the option of continuing with more aggressive drugs with the potential for more severe side effects. I elected euthanasia. My little man confirmed that I made the right decision: he died in my arms while my vet was on the way to my house.

Being faced with a cancer diagnosis is a devastating blow for cat parents. Making a decision about treatment is as individual as the affected cat and her human. There are no hard and fast rules. The ultimate goal of any decision is to provide good quality of life for the cat for as long as possible.

Have any of your cats undergone chemotherapy? What was your experience?

Photo ©Ingrid King

Dr. Goodpet



166 Responses to “Chemotherapy for Cats”

  1. Nancy Burgeson says:

    Hello there everyone, I am so glad I found this site tonight! We found out just 3-1/2 weeks ago our Belle has Lymphoma. She had a mass removed on her intestine but also has one that can not be removed. This has been the worst summer of my life! First my husband had a serious back surgery and then 7 weeks later I had rotator cuff surgery and am recovering from that. On May 31st we lost our 19 year old maine coon Willy to renal failure and dementia. I thought I was going to die as he was the love of my life. Then as I mentioned above just a couple weeks later we get hit with this and our little Belle who is 14 years. I had pretty much given up hope as she has been so very ill. Today my husband and I made the choice to try chemo and all of this posts have helped me to realize there may be hope for her too.
    Thanks so much folks!

    • Ingrid says:

      Oh Nancy, what a rough year you’ve had. All my best to Belle – let us know how she’s doing!

    • girlfriday says:

      My cat was also diagnosed with cancer a few weeks ago and unfortunately she passed as the cancer was so advanced but through research I found some holistic treatments for her. Maybe they will help you. They can be used in conjunction with chemo. Won’t hurt to try, right?

      • Ingrid says:

        I’m sorry about your kitty. I would be cautious using any type of holistic treatment without running it by your cat’s oncologist and/or holistic veterinarian. Herbal remedies in particular can interact with conventional drugs.

    • karen murray says:

      I grieve for your loss, and prayers to Bast for the success of the chemo. we recently helped send our oldest boy, 18+yrs old, Ra to the bridge, he had renal failure for over 2 yrs, then recently heart failure, he left on 8 apr….then on 25 apr mama cat was breathing hard, at this time she was diagnosed w/ heart failure…amon & a half later I took her back for breathing to fast, this time what the dr pulled off her chest was about 100cc of milky stuff it was lymphoma, the x-ray shows a lg spot on her rt side….we didn’t discuss chemo, I guess it is the size of the mass & that she is between 17 & 19. bless u and your family, I hope it works for you

    • Nancy Burgeson says:

      Hello there fellow cat lovers. I found this site on July 7th and also posted a comment at that time and hopefully you have had a chance to read it.
      I must say that I was really down in the dumps and also pretty scared to have our little Belle try chemo. She was so very ill-I really didn’t hold out much hope for her at that time. She has large cell Lymphoma which can be more difficult to treat then small cell.
      But, here it is one month later and things are going GREAT!!!!!! She has had 4 treatments and has a week off this week and has done really well. I am so thankful and surprised.
      She is also on prenidsolone and a schedule of 3 treatments-one each week and then a week off.
      Our little girl is eating again and looking out windows, chasing after treats and seems to be happy right now. I had told myself that if she suffered too much while on chemo that we would have to make a different decision but with her treatment going so well it is very encouraging. We are just thankful every day that she is with us! When she has her treatment, she even eats for the vet after it is administered and they really get a kick out of that. She is holding her own with weight, and gaining a few ounces each week.
      There is hope folks so never give up!!!!!

      • Ingrid says:

        Thank you for your update, Nancy. I’m so thrilled to hear that Belle is doing so well!

      • Diane says:

        Aloha Nancy. Thank you for the update on Belle.So happy she’s doing well. We have a little girl, Hoku who has lost a lot of weight rapidly, is getting very weak and the vet wants her to have an ultrasound to see if her problem is IBD or lymphoma. I’m wondering if Belle had lost a lot of weight and was really weak when you began the chemo or was her lymphoma found early on before she deteriorated much. Any more info would be greatly appreciated.

        • Nancy Burgeson says:

          I am sorry to hear that your little Hoku is not doing well. Regarding Belle, she was loosing weight prior to being diagnosed, but I didn’t think alot about it as she had been on weight reduction food for quite a while. I should have been quicker to no that she was ill as she was throwing up very frequently but I took her in for a check-up and all came back fine! About a month later I pressed the vet to see what else could be going on and that is when it was found. She was weak by this time as she really lost alot of weight.
          I was also having issues at this time with my 19 year old cat and he was fading away on us and I was spending alot of my energy on him.
          Ofcourse we always look back and wish this or that don’t we.
          Let me know when you find something out.

      • MARY says:

        Hi Nancy,

        Belle’s story sounds very similar to our ‘baby’ Sonny’s story. A big, strapping orange tabby, he was just diagnosed with large cell lymphoma last week, and immediately started chemotherapy the next day.

        We are still within that first week window, and take him back tomorrow for his 1 week checkup. For the first day or two after chemo, he seemed OK just lethargic. The prednisone apparently has helped his appetite.

        We were encouraged over the next few days, but then yesterday (5 days post-chemo) he seemed ‘down’ again, and just wanting to be left alone, eating less, etc.

        I see Belle had 4 treatments as of your August 9th posting and was wondering if you can remember how quickly after she initially started chemo that you saw a turnaround in her. I was sort of left to believe that we’d see an improvement almost immediately, the first week?

        Any details you could give me would be so appreciated. Thank you and I hope your ‘baby’ continues to be doing fine.


      • Caron Meloche says:

        I needed to hear that! Smokey is a 12-14 year old rescue kitty. I just found out today his lymphoma is T Cell and not B Cell. We’ve had one chemo treatment and will have his second in two days. I know T Cell is a more difficult to treat form of lymphoma. I have been reading about small cell and large cell lymphoma, small cell being more easily treated. Where does T Cell lymphoma fit, is it a small cell? Caron

  2. Liz Hardy says:

    A really interesting article, Ingrid; thanks so much. I agree with your raw feeding caution for cats with cancer – it depends how their appetites are, and whether you are adding meds to the food.

    As I’ve found with my own experience with my stripy little Moofy and her tumor (and the many cat guardians I talk to via the Meow Cancer Clinic), every furry little cancer patient is different – and the first rule has got to be Do No Harm.

  3. Mariza says:

    I am so glad I found this site
    We are still waiting on the blood test results to confirm the diagnose of small cell lypmhoma on Ginger intestine. We are devasted and lost. She just turn 13, she is very active and she have good and bad days, some days throw up and every day diarhea .
    Depending on the results we already decided that we are going to put her thru chemo. Though decision but I believe that she is a warrior and she will go thru this just fine. I can’t even imagine our life without her, she is such a playful, loving cat, she even has a little heart on her nose :)
    When I first got her she use to fit on my hands, she was so tiny.
    My heart is broken and I don’t know what to do.
    When are they going to find a cure for human and animal cancer God?

    • Ingrid says:

      All my best to Ginger as she goes through treatment, Mariza. Keep us posted on how she’s doing!

    • Robin says:

      Small cell lymphoma is very treatable. I give my kitty his chemo drug (3 pills)every 2 weeks and he is in total remission since last Jan. He regained all the weight he lost and to watch him, you’d never know he had lymphoma. Animals don’t usually get the side effects we think of when humans get chemo. From the tons of research I’ve done, they might lose their whiskers(mine didn’t )and might feel a little nauseous the day or two after getting the dose, but that is very treatable with an anti nausea pill. It was very scary when the diagnosis was finally made. For 2-3 months, he had a feeding tube, so I could get nourishment I to him. It was definitely worth those few months of difficult until his diagnosis was made and I brought him to an Oncologist. She made all the difference I. The world and changed his meds to the new “pulsing method” which means every 2 weeks instead of a more frequent low dose. There’s a very informative and active yahoo group for feline lymphoma where you will also get a wealth of info. It’s a scary diagnosis but is treatable!

      • Kelly says:

        Hi Robin, my little girl Leonna is going through her second battle of lymphoma. The first time she went into remission for 3 1/2 years. We used chemo and pred. She is 17 years old now and has come out of remission. I was wondering if you could explain the pulsing method you talked about in your message. Thanks!

        • robin says:

          The pulse method is a triple dose of chlorambucil (Leukeran)every 2 weeks. Most cats are also on pred, but mine isn’t because of its side effects. The Oncologist said pred wasn’t important after the initial treatment period and she was right. I’ve done a lot of research on it and am a member of 2 active Yahoo groups for Feline small cell ( for the most part…some large cell posters) and the more successful treatment seems to be the pulse regime. If your vet isn’t familiar with it, have him/her consult with an Oncologist at one of the large animal hospitals. My kitty goes to the biggest one in Boston. That’s where his regular vet is too. I’m lucky to be so close to them.

  4. Susan says:

    I am too very happy to find this website. My male cat, Baby, who is part Maine Coon and was a rescue has diagnosed back in February with lymphoma. He did really well on just a low dose of steriods for 4 months and then the vomiting started again. We just started him on a stronger dose of steriods and chlorambucil, which is very affordable. So far he seems like he is doing well. Still eating and only a minor loss in energy. He did urinate outside of the litter box this evening in the bathroom on one of the bath mats. I hope this isn’t going to be a re-occurence or issue with the medications. If anyone knows of any other side-effects to be wary of, please let me know. I’m really hoping that this regimen of medication will put the lymphoma into remission. I can’t imagine my life without my wonderful boy. Wishing all the other readers the best with their cats too.

    • Ingrid says:

      Contact your vet about Baby urinating outside the box, Susan. It may or may not be related to the medications, but in a cat with cancer, it’s important to address any potential medical issues immediately. All my best to your boy!

      • Susan says:

        Thanks very much Ingrid. We ended up purchasing another litter box for our 2nd floor so we could have it closer to where he spends most of the time and thankfully, no other incidents have occurred. I am bringing him to the vet soon to have him checked after being on the Chlorambucil for a few weeks and will discuss it with him if it happens again. I’m hoping that it was a one-off occurrence that might have been due to a smell or something he didn’t like on the mat.

    • Robin says:

      I’m glad your kitty was started on Chlorambucil. Steroids alone will not treat lymphoma. Initially, my kitty was on both and had to be weaned off of Prednisolone because it caused him to become diabetic. Eventually, the diabetes did go into remission, so he’s been on only Chlorambucil since the end of Feb. He’s been in remission since being switched to the every 2 week pulse regime last Jan by his oncologist and is back to being a thriving happy kitty. For the first month (Dec)he was on Chlorambucil twice a week and did not respond. Early on, he started urinating beside his box. As he stabilized and went into remission, that behavior stopped. He hasn’t done that since the end of Jan. His oncologist also put him on a stool softener, because chemo drugs usually cause constipation. My thoughts were that either he didn’t feel well enough to be sure footed to stand in litter or that he was constipated(which he was), and again, wanted a firmer surface to stand on. I accommodated him by putting 2 large plastic bags flat next to his box with a few paper towels on top. This kept it controlled and I just folded it up and put fresh supplies down after he went. He did use his litter box as well during this time and it was a problem every so often for about 3 weeks. Once he was feeling better, he stopped this behavior. I still, to this day, put the bags/paper towels there. After not going there for 5 months, a few weeks ago, he did deficate a tiny bit and it was very hard which told me he was constipated. I increased the number of times each week he gets the stool softener and he hasn’t done it since. He is still eating well and acting normally so I wasn’t concerned that anything else was wrong. He also gets a 4-6 week checkup with his oncologist and his blood work has been fine. You could also get training pads at the pet store instead of the bags.

      • Susan says:

        Thanks for your reply Robin. We ended up purchasing another litter box for our 2nd floor so we could have it closer to where he spends most of the time and thankfully, no other incidents have occurred. He doesn’t seem constipated as of yet. I am bringing him to the vet soon to have him checked after being on the Chlorambucil for a few weeks and will discuss it with him if it happens again. I’m hoping that it was a one-off occurrence that might have been due to a smell or something he didn’t like on the mat. We do have those pee-pee pads by the original litterboxes (I now have 3 in total now) because my other cat, a female occassionally will pee right outside the box or sometimes when he would pee, he’d be right by the end of the box and it would leak over the side. I can put those down around the new box as well. I’m glad your kitty is doing well with the chemotherapy and hope I have the same results with Baby. So far he’s been doing extremely well.

  5. Jeanette says:

    Our kitty Sugar was diagnosed with feline mammary cancer in January 2013. After her mastectomy chemo was not recommended, but she had a local recurrence 3 months later so after that lumpectomy chemo was recommended. She had 5 rounds of doxyrubicin and did great. She was never sick, in fact you would not have known she had cancer or that she was having chemo. Her only side effect was losing a few long whiskers which grew back. She was in remission for a year and shortly thereafter we found cancer in her lungs and chest and she made her bridge journey last May. I have no regrets about giving Sugar chemo. It is not the same as giving chemo to a human.

    • Susan says:

      So sorry to hear that you ended up losing Sugar but glad you were able to have a year longer with her. So far my Baby is doing well on the chemo. As long as he continues to do well with no issues, I’ll keep him on it. Agree that if there are no problems and they still have a quality of life with you, there should be no regrets.

      • Jeanette says:

        Thank you Susan.

        Sugar was a trooper and I had hoped she would beat her breast cancer. She was as sweet as her name and I miss her everyday. I am grateful for the high quality 16 months that we had after her initial diagnosis.

        I wish you and your Baby lots of high quality time together.

        • Susan says:

          Thank you Jeanette. Since he is only 10 1/2 years, it was heartbreaking to see him so sick at such a young age – considering that my two prior cats live to nearly 19 years each. He is so sweet too. All of the techs at the Vet love him because he is so docile and easily handled. My husband rescued him from under our deck. We ended up “inheriting” several feral cats when we bought our house and he was one of the rescues that we kept (along with another female, who was just diagnosed with asthma and is also on steroids).

          It’s always terrible to lose a beloved pet and my heart goes out to you. I hope you can find some peace and comfort in the wonderful memories you have of her.

          • Jeanette says:

            Thank you. Sugar was a favorite at the vet hospital too. When she died we got two sympathy cards filled with handwritten notes from the staff. She touched a lot of hearts and raised a lot of awareness too. A lot of people don’t know that animals get breast cancer and when she was diagnosed I started an organiztion to change that.

            I just did the Avon Breast Cancer Walk here in San Francisco and took “Sugar’ with me – I had a cutout of her and carried it on a poster all 39 miles. When we crossed the finish line people were cheering and yelling “Sugar, Sugar” – it was amazing. Of course I bawled my eyes out.

            A group of friends gave me some memorial windchimes. I have them hanging over a memorial garden stone in our backyard. Everyday that I’m at home I sit out there and eat lunch and listen to them – their tone is sweet and gentle and I like to think that sounding the chimes is Sugar’s way of letting me know she is close by.

            I know I will miss her always and I’m gratified that she is raising awareness even after her journey to the Rainbow Bridge.

  6. Jeanette says:

    Our kitty Chai was diagnosed with small cell GI lymphoma in August 2013. Initially we gave her Leukeran (chemo) in pill form 2mg every 3 days. She did not tolerate it well – she was very lethargic, weak and had no appetite. We gave her a short break of a week then tried 1 mg of Leukeran every other day. She is tolerating that regimen very well.

    • Susan says:

      Wishing your beloved Chai the best with the new regimen. My cat is taking Chlorambucil in pill form every other day and has only been on it a few days but so far is doing very well. I hope this will continue.

  7. Nancy Burgeson says:

    Mary, I am so very sorry to hear of your Sonny’s story. I guess I wouldn’t be too concerned yet as I think it is pretty normal to see some ups and downs for awhile. Also, our cats may be on a different chemo program. Our Belle does have days when she is pretty tired and not quite as willing to eat but it usually only lasts a day or two.
    We just have to take it a day at a time. There is no guarantee that this is going to work, so we just love her the days that she is still with us.
    Mary, if you have other questions please feel free to email me.

  8. Amanda Rynes says:

    I found out on Friday that Atlas, my six year old tabby, has intestinal lymphoma. I love the little guy more than anything in the world and, being so young, I expect many more happy years of headbutts, curling up under the covers and getting drooled on (yep, a drooling cat) when I got home. The vet said surgery wasn’t an option and told me chemo was more for the owner than the pet, so I opted for the prednisone route to make him as comfortable as possible. After reading the comments here I’m beginning to reconsider my options.

    I assumed that animals responded in a similar way and didn’t want to degrade his quality of life for my own benefit. The diagnosis was based on xrays and blood work so the type (large versus small cell) is unknown. The prednisone already seams to be increasing his appetite but he’s definitely groggy and not his usual lovey self. I’m terrified of loosing him so soon and would consider chemo. I’m not sure if I should ask another vets opinion, find out the type and proceed from there or do my best to make the time he has left as good as possible. Any and all thoughts are welcome.

    Thank you all for sharing your stories/thoughts/comments here, its was wonderful to find this page.

    • Ingrid says:

      I’m so sorry about Atlas’ diagnosis, Amanda. I would most definitely get a second opinion. Lymphoma cannot be definitely diagnosed with only bloodwork and x-rays. I would pursue further diagnostics and consult with a veterinary oncologist. Keep us posted, and all my best to both of you.

    • Lea-anne Martin says:

      my Kali was diagnosed August 2013 with digestive lymphoma and she is still with me as at October 2014. She lives a pretty quiet indoor life with morning garden walks. Daily Prednisolone and every three weeks she has a 4day dose of chemo Leukeran. She is in partial remission, lymph glands reduced but not normal. Every cat will respond differently, we tried a different chemo at one point but it no effect At All. Best of luck to you both.

      • Michelle says:

        Inspiring! My girl Kallie might be a “partial remission” kitty and I’m happy there’s hope for her. She has small cell GI lymphoma. I remember I was terrified to give chemo to her, but did it anyway because I all ways have the option to stop. I’m glad I tried it. She tolerates it well and her blood work is normal There was lethargy and nausea early, but that has passed. Kallie did well for a while (22 weeks). er stools were normal and she gained a pound. Now, I’m not so sure. Last Sunday, I gave her 1/4 of 15 mg of metrazidine last Sunday and she has had diarrhea since. I talked to the oncologist and tech that told me not to worry. I’ m worried anyway. If it doesn’t clear after tomorrow, I’m going to call her back and ask her if there’s any chance it’s the cancer. Ironically, the ultrasound completed a week ago today showed normal GI tract, and a few enlarged lymph nodes. If She doesn’t think it’s the cancer, I will may have the local vet check her kidneys. Anyone else have suggestions? Kallie’s current protocol is 2 mg chlormabucil every 3 days and 7.5 mg of prednisilone every other day. I will look into the pulse protocol. Kallie shouldn’t take the prediction long term because she has HCM, hyper trophic cardiomyopathy, which is heart disease. Thanks all for sharing!

    • robin says:

      I would also get a 2nd opinion. Is there an Oncologist you can take him to? My kitty started showing signs that something was wrong almost a year ago. It took a month to get the final diagnosis…lymphoma. He was started on pred and leukeran every day. After a month, there wasn’t any change, so last Jan, I switched him to see the head of Oncology at the same hospital. She switched him to the pulse protocol which is a triple dose of leukeran(3 pills), every 2 weeks. She weaned him off of the pred because it had caused him to become diabetic and he needed to get insulin shots twice a day. Luckily, the diabetes went into remission. No more shots! It took 2 months but he was completely off of the pred as of the end of Feb 2014. He did have a feeding tube from the beginning of Nov when he stopped eating, to the middle of Jan when, about 2 weeks after he started the pulse regime, he started eating a normal amount. The positive change was that quick. He put on the weight he’d lost and today, you’d never know he had cancer. He still gets Leukeran every 2 weeks and a stool softener every other day. I also give him Cerenia(anti nausea) the day he gets his chemo dose and the day after just as a precaution. His oncologist says he will live out his normal life now. He is 14.

    • Susan says:

      So sorry to hear about your beloved Atlas. My male cat, Baby was diagnosed with lymphoma back in February of this year. He was near death’s door, not eating at all for 2 days, gagging at the smell of food and was down 5 lbs from his healthy 14 lbs. The doctor sent him home with the lymphoma diagnosis and recommended pallative care with methylprednisolone (steroids) and told us he’s probably only last 6-8 weeks. He ended up doing well on the steroids until July and then starting getting sick again. I was very wary about putting him on chemotherapy and worried about the cost. However, after hearing cats tolerate it well and seeing him originally do so well on steroids alone thought I would try it – especially since it is affordable. So he is now on Prednisolone 5 mgs (steriods) twice a day and gets a Chlorambucil capsule for chemo every other day. He seems to be tolerating it extremely well and is mostly like his old self. He gained all of his weight back and is eating and enjoying both wet and dry food. He also still will play when the mood hits him and is very loving. The only downside I see is that he is a bit more tired on the days after he gets the chemo meds. He just turned 11 at the end of September and we are thankful for every day that he is still with us. From most of the posts, it looks like Leukeran is more popular than Chlorambucil but I don’t have any knowledge on if one is better than the other. Discuss both options with your vet and definitely get a 2nd opinion. I wish you and your Atlas all the best.

  9. robin says:

    correction,..when he was first started on a Leukeran, it was twice a week, not every day.

  10. Anna Caraveli says:

    I am so glad I found this site. Our 10-year old tabby was diagnosed with large cell lymphoma, under his left eye. At first the vet thought it was a tooth infection and then an eye infection. It took several weeks before he had a biopsy and diagnosis. This cancer was growing incredibly fast. You could see the growth by the day. His face looked distorted and swollen, his eye was completely squashed and had disappeared deep into the socket. His skin and blood vessels broke and blood was dripping down his face. It hurt just looking at him. He hid under beds and wouldn’t eat. I had heard the chemotherapy did nothing and turned to holistic meds but he kept declining and becoming deformed by the hour. Finally I took him to an oncologist who explained about chemo. His treatment plan was the modified Winsconsin protocol for cats–every week for 6 months. The first treatment was called Elspar and was the most intensive at all. The moment Alfie came home, he acted differently–started eating and purring and stopped hiding. The next day the difference was dramatic. The tumor had already started to go down, the vessels stopped bursting and his eye was open. Each day there was a dramatic improvement and by the end of the week he was looking almost normal. One day, he looked up at me and I realized that his bloody and broken eye was open. We all thought he had lost it but there he was, looking me in the eye.

    This is the end of the second week and he is due for his 3d treatment tomorrow. He looks completely normal. His eye is completely open and clear. I cannot see or feel his tumor any longer. He is playful, happy and fully back to his old self–in fact an invigorated Alfie. I never dreamed that it was biologically possible for any organism to heal that rapidly. The only worrisome thing is that everything I read says that there is an 80-90% chance that the cancer will come back. This is discouraging, though looking at him so happy and healthy is such a joy that it is hard to think of anything negative. I don’t think I could take it seeing him go back to the torture he endured. Any success stories about maintaining the remission?

    • Ingrid says:

      Thank you for sharing your experience, Anna – that’s a remarkable remission! Best wishes to you and Alfie.

    • robin says:

      I know the feeling. My kitty has been in remission since last Jan/Feb and is doing really well. There’s a part of me that keeps expecting the other shoe to drop. I just try to not think about it and enjoy whatever time he has. Hopefully, it will be many years!

    • Susan says:

      Anna – I’m so glad to hear your beloved boy is doing so well. My cat, Baby (male 10 years) was diagnosed with probable small cell gastric lymphoma back in February. He was basically at death’s door – had been sick since Nov/Dec, hadn’t eaten for 2 full days, was gagging at food and lost 5+ lbs in a short time.

      The vet started him on steroids initially and sent him home with the recommendation of palliative care only and gave him 6-8 weeks to live. I was concerned that the vet didn’t want to put him on chemotherapy at that time and did a lot of research myself to learn more about it regarding the success rate, the side effects and cost. I think the vet didn’t recommend it at that point because Baby was in such bad shape.

      Thankfully, he did extremely well on the steroids until late June and then he started to vomit again. The scans at that time showed the lymphoma was re-occurring. So we discussed the chemo with the vet. Since the vet said that 85-90% of cats will respond to treatment and it is very affordable (my cat is taking chlorambucil capsules every other day), we decided to go with the chemotherapy.

      He has been taking the chemo along with steroids twice a day since early July and hasn’t had a re-occurrence since then. I just took him for a follow-up at the vet yesterday and both his blood work and scan are normal/clear. He’s also gained all of the weight back and is now back up to 16.9 lbs.

      He seems very happy and back to his normal self and even plays occasionally. He does seem tired the day after he gets the chemo pill but I would expect that to be normal since he is 11 years old.

      I’m not sure how long the cancer will remain in remission. Some statistics say another 1.5-2 years but I’m hopeful it will be longer since he’s been doing so extremely well.

      Although our decision to go with the chemo is probably selfish, our cats aren’t suffering, are happy and healthy and have still have a wonderful quality of life where they are pampered and loved.

      I think we both made the right decision and shouldn’t have any doubts.

      I wish you and your boy all the best and hope for a very long remission!

      • Anna says:


        Thank you so much for your response and encouragement. Baby’s story is wonderful. So, if I understand it correctly, even after recurrence, Baby improved with chemotherapy and is healthy again? This is just amazing and so encouraging. I don’t know why my chemotherapy is so expensive. We have to take him to the Oncologist once a week and leave him there for the day. He is being treated with Vincristine one week and Cytoxan the following week. He didn’t mention chlorambucil but, even if he had, I wouldn’t know what it was or have a basis for choosing. But it’s good to know that there are more affordable drugs.

        Congratulations on the results of your last visit. I don’t think what you are doing is selfish at all. I think, on the contrary, it is selfless. I am sure you knew that your cat was not ready to go, just as I did. You see them fight hard and still enjoy little things in life and you just know that they are far from giving up. It’s only fair to help since help is available. His recovery proved you right. I am especially impressed that his cancer came back and you were still able to help him with chemo so that he is in remission again.

        All my best wishes for Baby.

        • Susan says:


          Just to clarify, Baby had the reoccurrence after being on only steroids for approx. 4 months from February to June. At that point, he started vomitting again and the vet saw the reoccurence of the mass in his stomach.

          He hadn’t been on the chemotherapy yet. Once we put him on the chemotherapy in June, he stopped vomiting, the mass receded and he was feeling much better. He has thankfully been in remission since then.

          The vet we have been taking him to recommended the Chlorambucil, which is the generic version of Leukeran and has been mentioned in some of the other posts here. It is very affordable. I pay about $40 total for a 30 day supply of capsules including shipping. And since he gets 1 pill every other day, I don’t have to order it every month.

          I get it from a mail-order pharmacy that the vet recommended. They are specialists in compounding drugs and can even put some of them in liquid form. I’ve stuck with pills for Baby since they work best with him. However, my female cat, Mimi has asthma and I give her the liquid, tuna flavored steroid nightly that I get from them.

          A friend’s daughter, who is a vet, recommended that we take him to an oncologist but we never did. I didn’t want to have Baby go through another whole barrage of tests especially when he wasn’t feeling well and also feel that the vet we are using is very knowledgeable and practical in all of the advice he gives us.

          It’s possible that Chlorambucil works better for some types of cancer and for your cat’s type, the Vincristine and Cytoxan work better. It might be worth a conversation with the vet to understand why that regimen was recommended and why Chlorambucil wasn’t considered.

          I’m thrilled that Baby is doing so much better. He’s a young 11 years of age and my prior two cats lived to 17 and 18 and I hope to have Baby as long as those two.

          I appreciate your words of support and best wishes.

          I wish you the same for you and your beloved boy! :-)

  11. Anna Caraveli says:

    Thank you both very much. Robin, it is so encouraging to hear that your kitty has been in remission since last Jan/Feb. It will soon be a year. How wonderful! I feel so much better hearing your story.

  12. Kaite says:

    My cat of 17 years has just commenced chemotherapy for GI small cell lymphoma – we are nearly a week in now. He is an otherwise healthy cat who is still as active as he was at 5 years of age. Therefore, treatment seems the best option for him, as it should hopefully maintain his good quality of life for as long as possible. I am hoping it is going OK. So far,he has not put on any weight, but seems good otherwise ( no diarrhea or vomiting since treatment commenced). I have heard that one can get a good idea of whether the cat is responding to treatment based on weight gain in the first few weeks. I am wondering whether the weight gain is instant, or whether it is not really apparent until a few weeks after treatment???

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